Reported Resistance Case(s)

Species: spodoptera litura

Order	Family	Common Name(s)	Group	Host
lepidoptera	noctuidae	mediterranean climbing cutworm	AG	Tobacco

Active Ingredient: flubendiamide

MOA: Ryanodine receptor modulators, Diamides
Group: DIA	CAS #: 272451	Shaugnessy Code: 0

Resistance Case(s)

Case Id	Year of Report	Type of Resistance	Location	Reference
G23473	2025	Field Evolved Resistance	China-- Guangdong-- Huizhou	Mei W, Yang G, Ye G, Yang Y, Wu Y. (2025). Differential contributions of the ryanodine receptor I4723M and I4723K mutations to diamide resistance in Spodoptera litura. Pestic Biochem Physiol, 208.
G23474	2025	Field Evolved Resistance	China-- Guangdong-- Huizhou	Mei W, Yang G, Ye G, Yang Y, Wu Y. (2025). Differential contributions of the ryanodine receptor I4723M and I4723K mutations to diamide resistance in Spodoptera litura. Pestic Biochem Physiol, 208.
G22544	2023	Field Evolved Resistance	China-- Fujian-- Ningde	Mei, W., Zuo, Y., Su, T., Yuan, J., Wu, Y., & Yang, Y. (2023). The ryanodine receptor mutation I4728M confers moderate-level resistance to diamide insecticides in Spodoptera litura. Pest management science, 79.

*The population was created solely by selection and/or genetic manipulation.
**The population was selected further in the laboratory after collection.